Azzarelli B, Meade P, Muller J
Childs Brain. 1980;7(3):132-45. doi: 10.1159/000119938.
The stage of regional structural and biochemical development of the central nervous system appears to be a critical factor determining the topistic distribution of 'hypoxic' lesions during the perinatal period. This report describes the brain lesions of 6 patients who suffered 'hypoxia' or ischemia during the perinatal period. 5 of these cases uniformly displayed symmetric ulegyria limited to areas of primary myelination, white matter damage subjacent to the cortical lesions, and status marmoratus of the basal ganglia and thalami. Areas of association which myelinate later in the postnatal period were basically normal. It is postulated that the damaged areas, at the moment of 'hypoxic' insult, had higher respiratory rates than the undamaged areas and, therefore, were more susceptible to oxygen deprivation.
中枢神经系统区域结构和生化发育阶段似乎是决定围产期“缺氧”性损伤拓扑分布的关键因素。本报告描述了6例在围产期遭受“缺氧”或缺血的患者的脑部病变。其中5例均表现为对称性脑回病变，局限于原发性髓鞘形成区域，皮质病变下方的白质损伤，以及基底神经节和丘脑的大理石样状态。在出生后期髓鞘形成较晚的联合区域基本正常。据推测，在“缺氧”损伤时，受损区域的呼吸频率高于未受损区域，因此更容易受到缺氧的影响。
