Omiecinski C J, Chao S T, Juchau M R
Dev Pharmacol Ther. 1980;1(1):90-100.
The rates of benzo[a]pyrene metabolism were stimulated markedly by micromolar quantities of hematin when assayed with either fetal or maternal extrahepatic tissue parparations (9,000 g supernatant fractions) from rats, rabbits and humans. Enzymatic induction was accompanied by either decreases in the magnitude of hematin stimulation or hematin-mediated inhibition of monooxygenase activities. Additions of 7,8-benzoflavone (BF) resulted in the inhibition of reaction rates in most experiments. With either fetal or maternal hepatic preparations from untreated rabbits, however, BF stimulated enzymatic activities; the greatest simulation occurred in fetal rabbit liver (10-fold). Nevertheless, inducer pretreatment was associated with inhibitory of BF on activities in hepatic homogenates.
当用大鼠、兔子和人类的胎儿或母体肝外组织匀浆（9000g 上清液部分）进行检测时，微摩尔量的血晶素能显著刺激苯并[a]芘的代谢速率。酶诱导伴随着血晶素刺激幅度的降低或血晶素介导的单加氧酶活性抑制。在大多数实验中，添加 7,8-苯并黄酮（BF）会导致反应速率受到抑制。然而，对于未处理兔子的胎儿或母体肝脏匀浆，BF 会刺激酶活性；在胎儿兔肝脏中刺激作用最为显著（10 倍）。尽管如此，诱导剂预处理与 BF 对肝匀浆活性的抑制作用有关。
