Hanukoglu A, Fried D, Gotlieb A
Eur J Pediatr. 1980 Aug;134(2):177-9. doi: 10.1007/BF01846042.
We describe a boy with an unusual adverse reaction to dyphenylhydantoin (DH). This 12 years old boy developed a clinical picture of high fever, scarlatiniform rash, a hemorrhagic (purpuric) skin lesion, on his buttocks and neck, stomatitis and conjunctivitis, within two weeks after DH administration. Laboratory examinations were compatible with the diagnosis of disseminated intravascular coagulation. Cases similar to ours are reviewed and it is stressed that DH should be used cautiously as it is not a harmless drug.
我们描述了一名对苯妥英（DH）出现异常不良反应的男孩。这个12岁的男孩在服用DH两周内出现了高热、猩红热样皮疹、臀部和颈部的出血性（紫癜性）皮肤损害、口腔炎和结膜炎的临床表现。实验室检查结果与弥散性血管内凝血的诊断相符。我们回顾了与我们病例相似的情况，并强调由于DH并非无害药物，应谨慎使用。
