Premel-Cabic A, Allain P, Pidhorz L, Streichenberger G
Eur J Clin Pharmacol. 1980 Nov;18(5):419-22. doi: 10.1007/BF00636796.
2-(p-methylallylaminophenyl) propionic acid, alminoprofene (INN), a new antalgic drug, was administered orally to men as a single (300 mg) and multiple doses (300 mg three times daily). Plasma and urine concentrations of alminoprofene were determined by gas-liquid chromatography. After the single oral dose, the peak plasma level (36.2 to 41.5 mg/l) was reached within 0.5 -1.5 h. the biological half-life ranged from 2.5 to 3.2 h. During chronic administration of alminoprofene, steady-state equilibrium was established within 24 h. The urinary excretion of alminoprofene as unchanged product and as glucuronide was very important.
2-（对甲基烯丙基氨基苯基）丙酸，阿明洛芬（国际非专利药品名称），一种新型镇痛药，以单次剂量（300毫克）和多次剂量（每日三次，每次300毫克）口服给予男性受试者。采用气液色谱法测定血浆和尿液中阿明洛芬的浓度。单次口服给药后，在0.5至1.5小时内达到血浆峰值水平（36.2至41.5毫克/升）。生物半衰期为2.5至3.2小时。在阿明洛芬的长期给药过程中，24小时内建立了稳态平衡。阿明洛芬以未变化产物和葡糖醛酸苷形式的尿排泄非常重要。
