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[脑和肾血管对高血压和低血压药物作用的联合反应]

[Combined reactions of the cerebral and renal vessels to the action of hypertensive and hypotensive agents].

作者信息

Beketov A I, Korneliuk I K

出版信息

Farmakol Toksikol. 1980 Jul-Aug;43(4):376-81.

PMID:7439372
Abstract

The action of noradrenaline (0.1-10 micrograms/kg), angiotensin (0.1-10 micrograms/kg), hemiton (30 micrograms/kg) and apressin (1 mg/kg) on the resistance of cerebral and renal vessels was studied in anesthesized cats by the two-channel resistography technique. It has been established that noradrenaline and angiotensin produce a synchronous vasoconstrictive effect in these organs, with the reaction to noradrenaline being less pronounced in renal vessels than in cerebral ones. Hemiton and apressin induce a stable vasodilatation in the brain and kidneys and attenuate vascular reaction to noradrenaline and angiotensin injections.

摘要

采用双通道电阻抗描记术,在麻醉猫身上研究了去甲肾上腺素(0.1 - 10微克/千克)、血管紧张素(0.1 - 10微克/千克)、海米托(30微克/千克)和加压素(1毫克/千克)对脑和肾血管阻力的作用。已经确定,去甲肾上腺素和血管紧张素在这些器官中产生同步的血管收缩作用,肾血管对去甲肾上腺素的反应不如脑血管明显。海米托和加压素可引起脑和肾的稳定血管舒张,并减弱对去甲肾上腺素和血管紧张素注射的血管反应。

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