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Analysis of the hypotensive action of prazosin.

作者信息

Constantine J W, McShane W K, Scriabine A, Hess H J

出版信息

Postgrad Med. 1975 Nov;Spec No:18-35.

PMID:1197141
Abstract

Results of animal studies indicate that the hypotensive effect of prazosin is due to vasodilatation which is dependent on two discernible components of drug action: (1) direct relaxation of vascular smooth muscle and (2) interference with peripheral sympathetic function at a site distal to the alpha-adrenergic receptor.

摘要

相似文献

1
Analysis of the hypotensive action of prazosin.
Postgrad Med. 1975 Nov;Spec No:18-35.
2
Interaction of atenolol with the systemic and regional hemodynamic effects of hydralazine in conscious renal hypertensive rabbits.阿替洛尔与肼屈嗪对清醒肾性高血压兔全身及局部血流动力学影响的相互作用。
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Effects of prazosin, an α1-adrenergic receptor antagonist, on the seeking and intake of alcohol and sucrose in alcohol-preferring (P) rats.哌唑嗪，一种 α1-肾上腺素能受体拮抗剂，对酒精偏爱（P）大鼠寻找和摄取酒精和蔗糖的影响。
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Supersensitivity of atherosclerotic rabbit aorta to ergonovine. Mediation by a serotonergic mechanism.动脉粥样硬化兔主动脉对麦角新碱的超敏反应。由5-羟色胺能机制介导。
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