Mustafaev M I, Kabanov V A
Farmakol Toksikol. 1980 Jul-Aug;43(4):395-9.
Mechanism of heparin interaction with the soluble complexes polyacrylamide (PA)--protein fractions of the whole serum has been examined. Addition of heparin to a mixture of the soluble complexes serum proteins (SP)--PA gives rise to the macromolecular reaction of protein replacement by negatively charged polysaccharide (heparin) according to the following scheme: (PA)--SP complex) plus heparin in equilibrium or formed from (PA--heparin complex) pus SP. Succession has been studied of heparin removal of different proteins from their polycation-including soluble complexes.
已对肝素与全血清可溶性复合物聚丙烯酰胺（PA）-蛋白质组分的相互作用机制进行了研究。向可溶性复合物血清蛋白（SP）-PA的混合物中添加肝素，会引发带负电荷的多糖（肝素）取代蛋白质的大分子反应，具体过程如下：（PA）-SP复合物加上肝素达到平衡，或由（PA-肝素复合物）与SP形成。研究了肝素从其含聚阳离子的可溶性复合物中去除不同蛋白质的顺序。
