[Mechanism of heparin binding by polycations in the presence of serum proteins].

Mechanism of heparin interaction with the soluble complexes polyacrylamide (PA)--protein fractions of the whole serum has been examined. Addition of heparin to a mixture of the soluble complexes serum proteins (SP)--PA gives rise to the macromolecular reaction of protein replacement by negatively charged polysaccharide (heparin) according to the following scheme: (PA)--SP complex) plus heparin in equilibrium or formed from (PA--heparin complex) pus SP. Succession has been studied of heparin removal of different proteins from their polycation-including soluble complexes.