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[去甲肾上腺素和钾离子对冠状动脉平滑肌细胞电活动及收缩活动的影响]

[Effect of noradrenaline and potassium ions on the electrical and contractile activity of coronary artery smooth muscle cells].

作者信息

Nikitina E I

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1980 Oct;66(10):1493-8.

PMID:7439440
Abstract

Smooth muscle cells (SMC) of circular strips from bovine and pig left descending anterior arteries responded to the increase of external potassium concentration from 5.9 to 160 mM with depolarization of the SMC membrane. At IK+I0 up to 40 mM this depolarization entailed relaxation of the strips; at IK+I0 from 40 mM to 80 mM the tonic contraction occurred. An increase of external potassium concentration up to 160 mM led to depolarization of the SMC membrane preceded by the AP. These changes were accompanied by initial phasic and subsequent tonic (potassium contracture) contractions. Noradrenaline (10(-5) M) added to the bathing solution induced membrane hyperpolarization and relaxation of the SMC, or relaxation without substantial shifts of the membrane potential level.

摘要

取自牛和猪左前降支动脉的环形条带中的平滑肌细胞(SMC),随着外部钾离子浓度从5.9 mM增加到160 mM,SMC膜发生去极化。在IK+I0高达40 mM时,这种去极化导致条带松弛;在IK+I0从40 mM到80 mM时,出现强直收缩。外部钾离子浓度增加到160 mM会导致SMC膜在动作电位(AP)之前发生去极化。这些变化伴随着最初的相性收缩和随后的强直(钾挛缩)收缩。加入到浴液中的去甲肾上腺素(10(-5) M)引起SMC膜超极化和松弛,或在膜电位水平无明显变化的情况下松弛。

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1
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Fiziol Zh SSSR Im I M Sechenova. 1980 Oct;66(10):1493-8.
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