Vitolo E, Ravizza P, Radice M, De Ambroggi L, Mariotti G, Folli G
G Ital Cardiol. 1980;10(4):386-92.
An ECG exercise test was performed in 36 patients with mitral stenosis, all in sinus rhythm and without digitalis therapy. In 21 subjects (group I = 58.6%) the test was negative, in the other 15 (group II = 41.7%) ischemic abnormalities of the ST segment were recorded during exercise; the mean value for the age is the same in both groups. All patients underwent cardiac catheterization; pulmonary pressure--and in 15 patients also cardiac output with thermodilution technique--were measured at rest and during the same exercise used for the ECG test. No relationship was found between ECG response and pulmonary capillary pressure (PCP), neither at rest nor during exercise, while exercise pressure values were well correlated with those at rest. The group I cardiac index (IC) and systolic index (IS) are significantly higher than in group II; the difference is remarkably more evident for the same indexes recorded during exercise, with splitting values, between the two groups, of 5000 ml/min/m2 for IC and 40 ml/beat/m2 for IS. Heart rate changes induced by exercise were similar in both groups, thus confirming the importance of the behaviour of output indexes. It is therefore possible to identify in mitral disease hemodynamic patterns due to different grouping of pathological features above (PCP) and below (IC) the valvular stenosis. Various hypothesis could be made in order to interpret the relationship between cardiac output and ischemic response to exercise. Anyway our results indicate that exercise ECG test is a non invasive technique useful to identify, among patients affected by mitral stenosis, those with a low IC and, mainly, those in whom this parameter fails to increase adequately with exercise.
对36例二尖瓣狭窄患者进行了心电图运动试验,所有患者均为窦性心律且未接受洋地黄治疗。21例受试者(第一组=58.6%)试验结果为阴性,另外15例(第二组=41.7%)在运动期间记录到ST段缺血性异常;两组的平均年龄相同。所有患者均接受了心导管检查;在静息状态以及与心电图试验相同的运动期间测量了肺动脉压——15例患者还采用热稀释技术测量了心输出量。无论是在静息状态还是运动期间,均未发现心电图反应与肺毛细血管压(PCP)之间存在关联,而运动时的压力值与静息时的压力值密切相关。第一组的心指数(IC)和收缩指数(IS)显著高于第二组;对于运动期间记录的相同指数,两组之间的差异更为明显,IC的差值为5000 ml/min/m²,IS的差值为40 ml/搏/m²。两组运动引起的心率变化相似,从而证实了输出指数变化的重要性。因此,在二尖瓣疾病中,可以根据瓣膜狭窄上方(PCP)和下方(IC)不同的病理特征分组来识别血流动力学模式。为了解释心输出量与运动缺血反应之间的关系,可以提出各种假设。无论如何,我们的结果表明,运动心电图试验是一种无创技术,有助于在二尖瓣狭窄患者中识别出IC较低的患者,主要是那些该参数在运动时未能充分增加的患者。