Gm 同种异型的定量研究。II. 健康高加索献血者血清中的 G1m(1)、G3m(5) 和 G3m(21)，以及一个具有负责弱 Gm1,17;..;21 单倍型基因遗传的家族。
Quantitative studies of Gm allotypes. II. G1m(1), G3m(5) and G3m(21) in sera from healthy caucasoid blood donors, and in a family with the inheritance of a gene responsible for a weak Gm1,17;..;21 haplotype.
作者信息
Rivat L, Salier J P, North M L, Oberling F R
出版信息
J Immunogenet. 1977 Dec;4(6):391-404. doi: 10.1111/j.1744-313x.1977.tb00923.x.
The quantitative expression of three allotypes--G1m(1), G3m(5) and G3m(21)--has been studied in normal caucasoid sera. A gene dosage effect, previously described for all of these allotypes, is not noticed for G3m(5) in the present study. The different content of G3m(5) and G3m(21) IgG3 molecules in heterozygous Gm5/Gm21 sera has been verified: these contents are respectively 75% and 25% of the IgG3 content. The same allotypes have been studied in a family which shows the inheritance of a weak Gm1,17;21 haplotype. The gene responsible for this abnormality is probably a new regulatory gene, and is transmitted without the 'aimed' haplotype.
在正常高加索人种血清中研究了三种同种异型——G1m(1)、G3m(5)和G3m(21)——的定量表达。本研究中未观察到先前针对所有这些同种异型所描述的基因剂量效应在G3m(5)上的表现。已证实杂合Gm5/Gm21血清中G3m(5)和G3m(21) IgG3分子的含量不同：这些含量分别为IgG3含量的75%和25%。在一个显示弱Gm1,17;21单倍型遗传的家族中对相同的同种异型进行了研究。导致这种异常的基因可能是一个新的调控基因，并且在没有“靶向”单倍型的情况下进行传递。
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