喂食与饥饿对胰腺切除猪体内免疫反应性胰高血糖素的影响。

The effect of feeding and starvation upon immunoreactive glucagon in the pancreatectomized pig.

作者信息

van Hoorn W A, Vinik A I, van Hoorn-Hickman R, Terblanche J

出版信息

Endocrinology. 1978 Feb;102(2):653-6. doi: 10.1210/endo-102-2-653.

Abstract

The response of 13 pigs to total pancreatectomy was compared with the response of 9 animals to sham operation. Approximately half of each group had free access to food while the remainder received oral water only. Completeness of pancreatectomy was confirmed at autopsy, and the disappearance of insulin and the rise in blood glucose to 14-19 mmol/l. Immunoreactive glucagon (IRG) increased in fed pancreatectomized pigs from the 3rd day postoperatively to a level of 350-400% of basal values by the 8th day. There was no rise in starved pancreatectomized animals, or in either group of sham-operated animals. The rises in glucose, free fatty acids, triglycerides and ketones were similar in the two groups of pigs.

摘要

将13头猪全胰切除的反应与9只动物假手术的反应进行了比较。每组大约一半的动物可自由获取食物，其余动物仅给予口服水。在尸检时确认了全胰切除的完整性，胰岛素消失，血糖升至14 - 19 mmol/l。术后第3天起，喂食的全胰切除猪体内免疫反应性胰高血糖素（IRG）增加，到第8天达到基础值的350 - 400%。饥饿的全胰切除动物或两组假手术动物体内均未出现升高。两组猪的血糖、游离脂肪酸、甘油三酯和酮的升高情况相似。