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[深静脉血栓形成(TVP)和肺栓塞的预防。肝素(每日3×5000国际单位)、肝素(每日2×5000国际单位)+0.5毫克双氢麦角碱以及物理治疗(间歇性加压袜+体育锻炼)的比较。与静脉造影和使用标记纤维蛋白原的腿部扫描相比,多普勒诊断在系统性检测TVP中的价值]

[Prevention of deep venous thrombosis (TVP) and pulmonary embolism. Comparison of heparin (3 x 5000 IU/day), heparin (2 x 5000 IU/day) + 0.5 mg dihydroergot, and physiotherapy (intermittent compression stockings + physical exercise). Value of Doppler diagnosis in systematic detection of TVP compared with phlebography and scanning of the legs using labelled fibrinogen].

作者信息

Moser G, Krähenbühl B, Donath A

出版信息

Helv Chir Acta. 1980 Jun;47(1-2):145-9.

PMID:7440192
Abstract

We compared the protective value of the above treatments in 227 randomised patients. Investigations in each patient included pulmonary scanning before and after operation, repeated postoperative Doppler and radioactive limb scanning completed by phlebography to confirm positive results. The heparin DHE group and the "physiotherapic" group each totalized 76 patients and the heparin group 75. These comparable groups show that HDHE and heparin prophylaxis are identical; but physiotherapy is perhaps better. Compared with phlebography leg scanning sensitivity is 95%, whilst it's specificity is 99%. Doppler sensitivity is only of 21%, whilst it's specificity is 95%. In conclusion, "physiotherapic" prophylaxis, including Flowtron, is as effective as heparin alone. Doses of heparin may be reduced, without loss of effect, if supplemented by a veinoconstrictive agent as DHE. The low Doppler sensitivity contraindicates its use in asymptomatic DVT detection.

摘要

我们比较了上述治疗方法对227例随机分组患者的保护作用。对每位患者的检查包括手术前后的肺部扫描、术后重复进行的多普勒检查以及通过静脉造影完成的放射性肢体扫描以确认阳性结果。肝素二氢麦角碱(DHE)组和“物理治疗”组各有76例患者,肝素组有75例。这些具有可比性的组表明,肝素二氢麦角碱和肝素预防效果相同;但物理治疗可能更好。与静脉造影相比,腿部扫描的敏感性为95%,而特异性为99%。多普勒检查的敏感性仅为21%,而特异性为95%。总之,包括血流动力治疗装置(Flowtron)在内的“物理治疗”预防方法与单独使用肝素一样有效。如果辅以静脉收缩剂如二氢麦角碱,肝素剂量可以减少而不影响效果。多普勒检查敏感性低,因此不适合用于无症状深静脉血栓(DVT)的检测。

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