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Tumor host relations. VI. Is alpha-ketoglutarate a tumor marker? Association with tumor extent in humans--correlation with tumor size in rats.肿瘤与宿主的关系。六、α-酮戊二酸是一种肿瘤标志物吗？与人类肿瘤范围的关联——与大鼠肿瘤大小的相关性。
J Cancer Res Clin Oncol. 1980;97(3):295-9. doi: 10.1007/BF00405781.
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本文引用的文献

1
Tumor host relations. IV. Tissue distribution of citric acid cycle intermediates and of glutamate in tumor-bearing rats high level of alpha-ketoglutarate in solid Yoshida sarcomas.肿瘤宿主关系。IV. 荷瘤大鼠体内柠檬酸循环中间产物及谷氨酸的组织分布——吉田实体肉瘤中α-酮戊二酸的高水平
J Cancer Res Clin Oncol. 1980;97(2):137-44. doi: 10.1007/BF00409899.
2
[Alpha-ketoglutaric acid increase in the blood and the localization and histology of malignant tumors].[血液中α-酮戊二酸水平升高与恶性肿瘤的定位及组织学]
Med Klin. 1969 Dec 5;64(49):2292-6.
3
[The blood levels of alpha-ketoglutaric acid at the various stages of the carcinoma of the cervix of the uterus (author's transl)].子宫颈癌各阶段的α-酮戊二酸血液水平（作者译）
Arch Gynakol. 1973;215(3):315-24. doi: 10.1007/BF00672815.
4
Tumor host relations. II. Increase of alpha-ketoglutarate in whole blood and urine and hypoalbuminemia of rats bearing the solid rhabdomyosarcoma BA 1112 and the ascitic or solid forms of Walker-carcinoma 256 and Yoshida-sarcoma.
J Cancer Res Clin Oncol. 1979 Apr 12;93(3):293-300. doi: 10.1007/BF00964586.

肿瘤与宿主的关系。六、α-酮戊二酸是一种肿瘤标志物吗？与人类肿瘤范围的关联——与大鼠肿瘤大小的相关性。

Tumor host relations. VI. Is alpha-ketoglutarate a tumor marker? Association with tumor extent in humans--correlation with tumor size in rats.

作者信息

Kronberger L, Semmelrock H J, Schaur R J, Schauenstein E, Schreibmayer W, Fink E

出版信息

J Cancer Res Clin Oncol. 1980;97(3):295-9. doi: 10.1007/BF00405781.

DOI:10.1007/BF00405781
PMID:7440629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12252805/
Abstract

A 4-year survey is presented on the alpha-ketoglutarate (KG) values in whole blood of 200 patients with malignant neoplasms mainly of the gastrointestinal tract and the female breast. A group of patients with benign surgical diseases served as control. KG showed an association with the extent of the primary tumor classified according to the TNM-scheme. The percentages of single values above the 2s-range of the control were as follows: T2: 18%,T3: 41%, and T4: 64%. The mean value of KG had highly significantly increased already in stage T2 as compared to the control group. Rats bearing the Yoshida sarcoma showed a significant correlation between the tumor size and the daily excretion of KG into urine during the early stage of tumor growth. The results suggested that KG cannot be regarded as an early tumor marker in humans, but may be of some value as an aid for the differential diagnosis in advanced tumor stages.

摘要

本文呈现了一项为期4年的调查结果，该调查针对200例主要患有胃肠道和女性乳腺癌恶性肿瘤患者的全血中α-酮戊二酸（KG）值展开。一组患有良性外科疾病的患者作为对照。KG与根据TNM分期系统分类的原发性肿瘤范围相关。高于对照组2s范围的单个值百分比分别为：T2期：18%，T3期：41%，T4期：64%。与对照组相比，在T2期KG的平均值就已显著升高。携带吉田肉瘤的大鼠在肿瘤生长早期，肿瘤大小与每日尿中KG排泄量之间存在显著相关性。结果表明，KG不能被视为人类的早期肿瘤标志物，但在晚期肿瘤阶段的鉴别诊断中可能具有一定价值。