Armstrong P B
J Cell Sci. 1980 Aug;44:263-71. doi: 10.1242/jcs.44.1.263.
When fragments of 2 dissimilar embryonic tissues are placed in contact in organ culture, cells of one fragment migrate over the surface of the second to envelop it. Holtfreter proposed that this behaviour was in response to 'tissue affinities'. He proposed that these also play important roles in the control of morphogenetic cell movement during development. The present study demonstrates that the heart fibroblast, present as a minority cell type in heart ventricle, can modify the affinity behaviour of heart tissue. The fibroblast effect appears to be mediated by a factor that can be extracted from living fibroblast monolayers by 1 M urea. The factor is a cell-surface protein since it is absent in monolayers which had been treated with trypsin prior to extraction.
当在器官培养中使两种不同的胚胎组织碎片相互接触时，一个碎片的细胞会迁移到另一个碎片的表面将其包裹起来。霍尔特弗雷特提出，这种行为是对“组织亲和力”的反应。他还提出，这些亲和力在发育过程中形态发生细胞运动的控制中也起着重要作用。本研究表明，作为心室中的少数细胞类型存在的心脏成纤维细胞，可以改变心脏组织的亲和力行为。成纤维细胞的作用似乎是由一种因子介导的，该因子可以用1M尿素从活的成纤维细胞单层中提取出来。该因子是一种细胞表面蛋白，因为在用胰蛋白酶处理过的单层中提取时它不存在。
