Delorme A C, Garel J M, Mathieu H
J Dev Physiol. 1980 Feb-Apr;2(1-2):47-52.
In rats, the intestinal concentration of immunoreactive Ca-binding protein was shown to increase at weaning. We now report that injections of 1,25-dihydroxycholecalciferol (1,25(OH)2D3, 25 ng or 10 ng/day) in suckling rats on days 11, 12 and 13 induce a premature rise of the intestinal Ca-binding protein concentrations, associated with increased plasma Ca concentrations. No effect is seen after 25-hydroxycholecalciferol, or after hydrocortisone administration. L-Thyroxine, at high doses (50 micrograms/day) and at more physiological doses (2 micrograms/day) induces a significant rise of the intestinal Ca-binding protein concentrations and a decrease of plasma Ca concentrations. The association of 1,25(OH)2D3 (at 10 ng/day) and L-thyroxine (at 2 micrograms/day) does not cause an additive effect on Ca-binding protein concentrations and does not change plasma Ca. These results suggest that 1,25(OH)2D3 and thyroxine are probably involved in the regulatory mechanisms of the intestinal Ca-binding protein synthesis at weaning.
在大鼠中，免疫反应性钙结合蛋白的肠道浓度在断奶时会升高。我们现在报告，在出生后第11、12和13天给乳鼠注射1,25 - 二羟胆钙化醇（1,25(OH)₂D₃，25 ng或10 ng/天）会导致肠道钙结合蛋白浓度过早升高，并伴有血浆钙浓度升高。25 - 羟胆钙化醇注射后或给予氢化可的松后未见效果。高剂量（50微克/天）和更接近生理剂量（2微克/天）的L - 甲状腺素会导致肠道钙结合蛋白浓度显著升高以及血浆钙浓度降低。1,25(OH)₂D₃（10 ng/天）和L - 甲状腺素（2微克/天）联合使用对钙结合蛋白浓度没有叠加效应，也不会改变血浆钙。这些结果表明，1,25(OH)₂D₃和甲状腺素可能参与了断奶时肠道钙结合蛋白合成的调节机制。
