Longnecker D S, Curphey T J, Lilja H S, French J I, Daniel D S
J Environ Pathol Toxicol. 1980 Aug;4(1):117-29.
The carcinogenicity of the nitrosourea amino acid, N delta-(N-methyl-N-nitrosocarbamoyl)-L-ornithine (MNCO), and its acute cytotoxicity were studied in Wistar rats. MNCO treatment induced a high incidence of neoplasms in breast, kidney, and skin and a lower incidence of tumors in the exocrine pancreas and ear duct. The duration of these studies was limited by toxicity and carcinogenicity to six months in a high dose group which received 1 mmole MNCO/kg IP weekly for 6 months and to 1 year in a group which received 0.33 mmole/kg. In the latter group the incidence of neoplasms was breast, 40%; skin, 52%; kidney, 81%; pancreas, 19%; and ear duct, 4%. All pancreases in this group also contained foci of fibrosis and cyst formation, and atypical acinar cell nodules. Acute cytotoxic effects were noted in pancreas, kidney and skin after a single IP injection of 3 mmoles/kg although this dose caused no deaths acutely.
在Wistar大鼠中研究了亚硝基脲氨基酸Nδ-（N-甲基-N-亚硝基氨基甲酰基）-L-鸟氨酸（MNCO）的致癌性及其急性细胞毒性。MNCO处理导致乳腺、肾脏和皮肤的肿瘤发生率很高，而外分泌胰腺和耳道的肿瘤发生率较低。这些研究的持续时间因毒性和致癌性而受到限制，高剂量组每周腹腔注射1 mmol MNCO/kg，持续6个月，该组研究持续6个月；另一组接受0.33 mmol/kg，研究持续1年。在后一组中，肿瘤发生率为：乳腺40%；皮肤52%；肾脏81%；胰腺19%；耳道4%。该组所有胰腺还存在纤维化灶、囊肿形成以及非典型腺泡细胞结节。单次腹腔注射3 mmol/kg后，在胰腺、肾脏和皮肤中观察到急性细胞毒性作用，尽管该剂量未导致急性死亡。
