Polednak A P
J Environ Pathol Toxicol. 1980 Aug;4(1):457-70.
Fertility was examined in 199 women exposed to internal and external radiation while employed in the radium watch-dial painting industry in Illinois between 1916 and 1929. In women with at least one live birth, mean log live-birth rate was significantly lower in the highest (estimated) ovarian-dose group (i.e., greater than or equal to 20 rem) than in the lowest group (< 5 rem). In multiple regression analysis, intake dose (proportional to alpha-particle dose to ovaries) but not duration of employment (relevant to external gamma-ray dose to ovaries) was a statistically significant predictor of log live-birth rate. There was no evidence for an increase in fetal deaths with increasing ovarian dose level (rem). This suggests that the findings on live-birth rate may not involve post-implantation dominant lethal mutations, but preimplantation losses could not be evaluated. Some possible explanations for these findings are discussed.
对1916年至1929年间在伊利诺伊州镭表盘涂漆行业工作时遭受内、外辐射的199名女性的生育能力进行了研究。在至少有一次活产的女性中，最高（估计）卵巢剂量组（即大于或等于20雷姆）的平均活产率对数显著低于最低剂量组（<5雷姆）。在多元回归分析中，摄入剂量（与卵巢的α粒子剂量成正比）而非就业时长（与卵巢的外照射γ射线剂量相关）是活产率对数的统计学显著预测因素。没有证据表明随着卵巢剂量水平（雷姆）的增加，胎儿死亡会增加。这表明活产率的研究结果可能不涉及植入后显性致死突变，但无法评估植入前的损失。文中讨论了这些发现的一些可能解释。
