Karwoski C J, Proenza L M
J Gen Physiol. 1980 Oct;76(4):479-97. doi: 10.1085/jgp.76.4.479.
Responses to repetitive stimulation were monitored at several retinal levels in the eyecup of the mudpuppy Necturus maculosus. When alternating sequences of low-intensity small and large spots were presented, two effects were found, which could be localized to the proximal retina: (a) response decrement (RD), in which, after the first small spot response, subsequent small spot responses are decreased in amplitude and (b) transient response enhancement (TRE), in which the first small spot response after a large spot sequence is larger than preceding or subsequent small spot responses. RD and TRE are absent or weak in sustained on or off responses (horizontal and bipolar cells, and ON and OFF ganglion cell post-stimulus time histograms (PSTH) but are particularly well developed in the on/off responses of the proximal retina (proximal negative response, M-wave, PSTHs of ON/OFF ganglion cells, and intracellular responses from on/off neurons and Müller cells). RD and TRE appear to arise from a stimulus-evoked slow depolarization in on/off neurons that interacts with the amplitude of succeeding responses. We conclude that RD and TRE are a form of neural adaptation that is largely specific to the on/off channels of the proximal retina.
在泥螈（Necturus maculosus）眼杯的几个视网膜层面监测对重复刺激的反应。当呈现低强度小光斑和大光斑交替序列时，发现了两种效应，它们可定位于近端视网膜：（a）反应递减（RD），即第一个小光斑反应后，后续小光斑反应的幅度减小；（b）瞬态反应增强（TRE），即大光斑序列后的第一个小光斑反应大于之前或之后的小光斑反应。RD和TRE在持续的开或关反应（水平细胞和双极细胞，以及ON和OFF神经节细胞的刺激后时间直方图（PSTH））中不存在或较弱，但在近端视网膜的开/关反应（近端负反应、M波、ON/OFF神经节细胞的PSTH，以及开/关神经元和米勒细胞的细胞内反应）中特别明显。RD和TRE似乎源于开/关神经元中刺激诱发的缓慢去极化，该去极化与后续反应的幅度相互作用。我们得出结论，RD和TRE是一种神经适应形式，在很大程度上特定于近端视网膜的开/关通道。
