发育中小鼠小脑平行纤维的瞬时伴刀豆球蛋白A结合糖蛋白：其聚糖被破坏的证据

Transient concanavalin A-binding glycoproteins of the parallel fibres of the developing rat cerebellum: evidence for the destruction of their glycans.

作者信息

Reeber A, Vincendon G, Zanetta J P

出版信息

J Neurochem. 1980 Dec;35(6):1273-7. doi: 10.1111/j.1471-4159.1980.tb08998.x.

DOI:10.1111/j.1471-4159.1980.tb08998.x

Abstract

The lifetime of the glycoprotein glycans of the rat cerebellum was followed in the 2nd and 3rd weeks of postnatal age, after injection of labelled glucosamine. It appears that a particular class of glycans binding to Concanavalin A synthesized at an early age has a short lifetime. These results indicate that the glycans of the concanavalin A-binding glycoproteins abundant on the newly formed parallel fibres are rapidly degraded between the 14th and the 18th postnatal day.

摘要

在注射标记的葡糖胺后，对出生后第2周和第3周大鼠小脑糖蛋白聚糖的寿命进行了跟踪研究。结果显示，一类在早期合成的、与伴刀豆球蛋白A结合的特定聚糖寿命较短。这些结果表明，在新生平行纤维上大量存在的伴刀豆球蛋白A结合糖蛋白的聚糖在出生后第14天到第18天之间迅速降解。