Trimble M R, Corbett J A, Donaldson D
J Neurol Neurosurg Psychiatry. 1980 Nov;43(11):1030-4. doi: 10.1136/jnnp.43.11.1030.
312 children resident at a hospital school received a neuropsychiatric examination and information was provided on their IQ status. Children with a fall in their IQ were identified. Serum and red cell folate values were estimated and the relationship between neuropsychiatric disturbances and folate disturbances explored. Patients with a fall in IQ, neurotic disturbance and depression all had significantly lower serum folic acid levels than the rest of the population, and the children with neurotic disturbances and depression had significantly lower red cell folate values. The relationship between folic acid metabolism and the neuropsychiatric disturbances is discussed in the light of these findings.
312名住在医院学校的儿童接受了神经精神检查，并提供了他们的智商状况信息。识别出智商下降的儿童。测定了血清和红细胞叶酸值，并探讨了神经精神障碍与叶酸紊乱之间的关系。智商下降、神经症性障碍和抑郁症患者的血清叶酸水平均显著低于其他人群，患有神经症性障碍和抑郁症的儿童红细胞叶酸值显著较低。根据这些发现讨论了叶酸代谢与神经精神障碍之间的关系。
