Merikanto J, Ruuskanen O, Eskola J, Ruutu P, Louhimo I
J Pediatr Surg. 1980 Oct;15(5):651-4. doi: 10.1016/s0022-3468(80)80518-5.
The hazard of overwhelming postsplenectomy infection has been suggested to be greatest in children operated upon before 1 yr of age. In this work immune functions of 3 children, splenectomized within 2 days after birth were studied. The opsonic activity of the sera of all patients towards pneumococcus was decreased. The other immunologic findings were normal. These observations support the concept that all splenectomized patients should receive pneumococcal polysaccharide vaccine and in case of any infection adequate antibiotic therapy must be started very soon after the first symptoms.
有人提出，脾切除术后严重感染的风险在1岁前接受手术的儿童中最大。在这项研究中，对3名出生后2天内接受脾切除术的儿童的免疫功能进行了研究。所有患者血清对肺炎球菌的调理活性均降低。其他免疫学检查结果正常。这些观察结果支持这样一种观点，即所有脾切除患者都应接种肺炎球菌多糖疫苗，并且一旦发生任何感染，必须在出现最初症状后尽快开始充分的抗生素治疗。
