Matthiesen T, Tuch K
Exp Pathol (Jena). 1978;15(6):341-7. doi: 10.1016/s0014-4908(78)80041-6.
The morphological findings in spontaneously hypertensive rats (SHR) were compared with the findings after experimental renal hypertension. In addition the effect of an arteriosclerogenic diet was investigated. Cardiac hypertrophy occurred in all types of hypertension. During the course of renal hypertension there was also hypertrophy of the tunica media of the arterial vessels of the heart, kidneys, mesenterium, and orta. Degenerative changes in the vascular walls occurred when nephrectomized rats were given a diet containing 2% cholesterol and 1% cholic acid. This produced intima lipoidosis after seven to eleven weeks. The intensity seemed to be dependent on the degree of hypertension and the duration of the experiment.
将自发性高血压大鼠（SHR）的形态学结果与实验性肾性高血压后的结果进行了比较。此外，还研究了致动脉粥样硬化饮食的作用。所有类型的高血压均出现心脏肥大。在肾性高血压过程中，心脏、肾脏、肠系膜和主动脉的动脉血管中膜也出现肥大。当给肾切除的大鼠喂食含2%胆固醇和1%胆酸的饮食时，血管壁会发生退行性变化。这在7至11周后会导致内膜类脂沉积。其严重程度似乎取决于高血压的程度和实验持续时间。
