一些11H-吲哚并[3,2-c][1,8]萘啶的合成。
Synthesis of some 11H-indolo[3,2-c][1,8]naphthyridines.
作者信息
Da Settimo A, Biagi G, Primofiore G, Ferrarini P L, Livi O
出版信息
Farmaco Sci. 1978 Oct;33(10):770-80.
PMID:744236
Abstract
The preparation of some 11H-indolo[3,2-c] [1,8]naphthyridines (V), having oxygen functions at positions 3 or 3 and 10 or 3 and 8, as in steroidal active compounds, is described. Compounds (V) were obtained using the Fisher indole synthesis. The preparation of the parent nucleus: 11H-indolo [3,2-c] [1,8]naphthyridines (V n) is also described. Some compounds were subjected to pharmacological screening, but none was found to be significantly active.
摘要
描述了一些11H-吲哚并[3,2-c][1,8]萘啶（V）的制备方法，这些化合物在3位或3位和10位或3位和8位具有氧官能团，如同甾体活性化合物那样。化合物（V）是通过费歇尔吲哚合成法得到的。还描述了母核11H-吲哚并[3,2-c][1,8]萘啶（V n）的制备。一些化合物进行了药理筛选，但未发现有显著活性。
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