Sparatore F, La Rotonda M I, Ramundo E, Silipo C, Vittoria A
Farmaco Sci. 1978 Dec;33(12):924-44.
The action on plant growth of sixty benzotriazole derivatives carrying on position 1 or 2 several kinds of substituents, has been studied via the oat coleoptile section elongation test. At medium and low concentrations almost all compounds behave as activators, while at the highest concentrations many of them, like indolylacetic acid (IAA), are growth inhibitors. It is worth noting the lack of toxicity, even at the highest concentration used, for the 1-hydroxyalkylbenzotriazoles and, more generally speaking, the low toxicity of hydroxyalkylbenzotriazoles and of benzotriazolylalkanoic acid amides. In the range of concentration from 10(-6) to 10(-8) M some methylalkylbenzotriazoles as well as some benzotriazolylalkanoic acids and esters are more active than IAA exhibiting from 40 to 60% of the maximal activity of IAA. The activities of methylalkylbenzotriazoles and particularly that of 2-(1'-methyl)pentylbenzotriazole are outstanding; actually at the lowest concentration tested (10(-8) M and at 10(-5) M, at which concentration this compound shows the maximum activity, the biological responses correspond respectively to more than 50 and 80% of maximal activity of IAA.
通过燕麦胚芽鞘切段伸长试验,研究了60种在1位或2位带有多种取代基的苯并三唑衍生物对植物生长的作用。在中低浓度下,几乎所有化合物都表现为生长促进剂,而在最高浓度下,其中许多化合物,如吲哚乙酸(IAA),则是生长抑制剂。值得注意的是,即使在所用的最高浓度下,1-羟烷基苯并三唑也没有毒性,更一般地说,羟烷基苯并三唑和苯并三唑基链烷酸酰胺的毒性较低。在10^(-6)至10^(-8) M的浓度范围内,一些甲基烷基苯并三唑以及一些苯并三唑基链烷酸和酯比IAA更具活性,表现出IAA最大活性的40%至60%。甲基烷基苯并三唑的活性,特别是2-(1'-甲基)戊基苯并三唑的活性非常突出;实际上,在测试的最低浓度(10^(-8) M)以及该化合物显示最大活性的10^(-5) M浓度下,生物反应分别相当于IAA最大活性的50%以上和80%。