Scholfield C N
Naunyn Schmiedebergs Arch Pharmacol. 1980 Oct;314(1):29-36. doi: 10.1007/BF00498428.
The effects of some gamma-aminobutyric acid (GABA) antagonists and other "convulsants" have been tested on neurones of the isolated olfactory cortex slice preparation of the guinea-pig using single cell intracellular and gross extracellular recording techniques. Bicuculline, picrotoxin, strychnine, leptazol, bemegride, and also theophylline and d-tubocurarine all increased the duration and amplitude of the excitatory postsynaptic potential, thereby producing a seizure-like discharge. These drugs reduced and shortened the peak conductance increase during the inhibitory postsynaptic potential (i.p.s.p.) in normal solution and after the i.p.s.p. had been prolonged by the presence of a barbiturate. The results suggested that these drugs antagonise synaptic inhibition through a common mechanism, perhaps by reducing the effect of neurally released GABA.
使用单细胞细胞内记录和总体细胞外记录技术，在豚鼠离体嗅皮质切片标本的神经元上测试了一些γ-氨基丁酸（GABA）拮抗剂和其他“惊厥剂”的作用。荷包牡丹碱、印防己毒素、士的宁、戊四氮、贝美格，以及茶碱和d-筒箭毒碱均增加了兴奋性突触后电位的持续时间和幅度，从而产生癫痫样放电。在正常溶液中以及在巴比妥酸盐延长抑制性突触后电位（i.p.s.p.）后，这些药物均降低并缩短了i.p.s.p.期间峰值电导的增加。结果表明，这些药物通过共同机制拮抗突触抑制，可能是通过降低神经释放的GABA的作用来实现的。
