豚鼠新皮层和嗅皮层神经元中的自发性抑制性突触后电位

Spontaneous inhibitory postsynaptic potentials in guinea pig neocortex and olfactory cortex neurones.

作者信息

Galvan M, Franz P, Constanti A

出版信息

Neurosci Lett. 1985 Jun 12;57(2):131-5. doi: 10.1016/0304-3940(85)90051-5.

Abstract

The membrane potential of olfactory cortex and neocortex neurones in vitro was recorded using conventional microelectrode techniques. During recordings with KCl- or CsCl-filled microelectrodes, spontaneous, subthreshold, transient membrane depolarizations were observed. These were abolished by the GABAA-receptor antagonist, bicuculline methiodide, and were prolonged by the barbiturate pentobarbitone. In most cells they were abolished by tetrodotoxin. It is concluded that these spontaneous depolarizations are inhibitory postsynaptic potentials arising from spontaneous activity in inhibitory interneurones.

摘要

采用传统微电极技术记录体外培养的嗅觉皮层和新皮层神经元的膜电位。在用填充氯化钾或氯化铯的微电极记录过程中，观察到自发的、阈下的、短暂的膜去极化现象。这些现象可被GABAA受体拮抗剂甲磺酸荷包牡丹碱消除，并被巴比妥类药物戊巴比妥延长。在大多数细胞中，它们可被河豚毒素消除。得出的结论是，这些自发去极化是由抑制性中间神经元的自发活动产生的抑制性突触后电位。