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[右旋筒箭毒碱对胎儿和新生儿有危险吗?]

[Is d-tubocurarine dangerous for the fetus and the newborn infant?].

作者信息

Melloni C, Cantamessa G, Macchiagodena C, Bonora M, Zanello M

出版信息

Minerva Anestesiol. 1980 Mar;46(3):387-94.

PMID:7443054
Abstract

A survey of a series of caesarean section done under general anesthesia with the aid of muscle relaxation obtained by repeated doses of d-tubocurarine evidenced a tendency to worsen the Apgar index. In the light of the cases and from the literature some hypotheses are here discussed; the most reliable are based upon the fact that injections of the curare before the plasma half life of the drug end by increasing the materno foetal gradients permitting the transplacentar passage of the d-tubocurarine.

摘要

一项关于在全身麻醉下借助重复剂量的右旋筒箭毒碱获得肌肉松弛进行的一系列剖宫产手术的调查表明,阿氏评分有恶化的趋势。根据这些病例并结合文献,在此讨论了一些假设;最可靠的假设基于这样一个事实,即在药物血浆半衰期结束前注射箭毒会增加母胎梯度,从而使右旋筒箭毒碱能够通过胎盘。

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