癌胚抗原水平的动态变化。晚期胃肠道癌联合化疗疗效及复发的预测指标。
Sequential carcinoembryonic antigen levels. A predictor of response and relapse in combination chemotherapy of advanced gastrointestinal cancer.
作者信息
Ichiki A T, Krauss S, Israelsen K L, Sonoda T, Collmann I R
出版信息
Oncology. 1981;38(1):27-30. doi: 10.1159/000225516.
Serial determinations of plasma carcinoembryonic antigen (CEA) levels were assayed for 34 patients with advanced gastrointestinal cancer undergoing 5-fluorouracil and mitomycin C combination chemotherapy. 21 patients (62%) had an objective response and the CEA level was decreased in 12. After chemotherapy was initiated a rise in CEA level occurred on the average 6.5 months later, while the mean time to clinical relapse was 8 months. 5 patients (15%) had stable disease; the CEA level was decreased in 2. In 8 patients (24%) with progressive disease, the mean time for a rising CEA level was 3 months. In our view, a change in the CEA level reflects the effectiveness of combination chemotherapy in patients with advanced gastrointestinal cancer.
对34例接受5-氟尿嘧啶和丝裂霉素C联合化疗的晚期胃肠道癌患者进行了血浆癌胚抗原（CEA）水平的系列测定。21例患者（62%）有客观反应，其中12例CEA水平下降。化疗开始后，CEA水平平均在6.5个月后升高，而临床复发的平均时间为8个月。5例患者（15%）病情稳定，其中2例CEA水平下降。在8例病情进展的患者（24%）中，CEA水平升高的平均时间为3个月。我们认为，CEA水平的变化反映了联合化疗对晚期胃肠道癌患者的疗效。
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