肝素、游离脂肪酸以及对氧气代谢需求的增加。
Heparin, free fatty acids and an increased metabolic demand for oxygen.
作者信息
Jung R T, Shetty P S, James W P
出版信息
Postgrad Med J. 1980 May;56(655):330-2. doi: 10.1136/pgmj.56.655.330.
Abstract
Obese and lean subjects were given heparin with or without Intralipid in order to assess the effect of heparin on plasma concentration of free fatty acids (FFA) and oxidative metabolism. The FFA response depended on the triglyceride concentration and was associated with a prompt rise in oxygen consumption. Plasma catecholamines did not alter after heparin and the increase in oxygen uptake was proportional to the rise in FFA. The use of heparin, therefore, has metabolic disadvantages which may outweigh the potential benefits, for example in the management of myocardial infarction where heparin may increase the metabolic demand on the heart by increasing FFA levels.
摘要
为了评估肝素对游离脂肪酸（FFA）血浆浓度和氧化代谢的影响，对肥胖和消瘦受试者给予肝素，同时或不给予脂肪乳剂。FFA反应取决于甘油三酯浓度，并与耗氧量迅速增加有关。肝素注射后血浆儿茶酚胺没有变化，摄氧量的增加与FFA的升高成正比。因此，使用肝素存在代谢方面的弊端，这些弊端可能超过潜在益处，例如在心肌梗死的治疗中，肝素可能通过提高FFA水平增加心脏的代谢需求。
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