吲哚洛尔诱发的震颤。
Pindolol-induced tremor.
作者信息
Hod H, Har-Zahav J, Kaplinsky N, Frankl O
出版信息
Postgrad Med J. 1980 May;56(655):346-7. doi: 10.1136/pgmj.56.655.346.
Abstract
Five patients were treated with pindolol for various indications. The patients called attention to the appearance of fine tremors in their extremities 6-72 hr after starting treatment with the drug. The tremors disappeared 24-72 hr after stopping the drug. Beta-adrenoceptor-blockers are known to suppress different types of tremor and the paradoxical appearance of tremors during pindolol treatment is attributed to its powerful partial agonist activity. To the best of the authors' knowledge this side effect has not been previously described in the literature.
摘要
五名患者因各种适应症接受了吲哚洛尔治疗。患者在开始使用该药物治疗6 - 72小时后注意到四肢出现细微震颤。停药后24 - 72小时震颤消失。已知β - 肾上腺素受体阻滞剂可抑制不同类型的震颤，而吲哚洛尔治疗期间震颤的反常出现归因于其强大的部分激动剂活性。据作者所知，这种副作用此前在文献中尚未有描述。
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