吲哚洛尔诱发的震颤。
Pindolol-induced tremor.
作者信息
Hod H, Har-Zahav J, Kaplinsky N, Frankl O
出版信息
Postgrad Med J. 1980 May;56(655):346-7. doi: 10.1136/pgmj.56.655.346.
Abstract
Five patients were treated with pindolol for various indications. The patients called attention to the appearance of fine tremors in their extremities 6-72 hr after starting treatment with the drug. The tremors disappeared 24-72 hr after stopping the drug. Beta-adrenoceptor-blockers are known to suppress different types of tremor and the paradoxical appearance of tremors during pindolol treatment is attributed to its powerful partial agonist activity. To the best of the authors' knowledge this side effect has not been previously described in the literature.
摘要
五名患者因各种适应症接受了吲哚洛尔治疗。患者在开始使用该药物治疗6 - 72小时后注意到四肢出现细微震颤。停药后24 - 72小时震颤消失。已知β - 肾上腺素受体阻滞剂可抑制不同类型的震颤，而吲哚洛尔治疗期间震颤的反常出现归因于其强大的部分激动剂活性。据作者所知，这种副作用此前在文献中尚未有描述。
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本文引用的文献
1
Beta-adrenergic blockade in the management of acute thyrotoxic crisis, tachycardia and arrhythmias.
Postgrad Med J. 1967 Dec;43(506):756-62. doi: 10.1136/pgmj.43.506.756.
2
Peripheral beta-adrenergic receptors concerned with tremor.
Clin Sci. 1967 Aug;33(1):53-65.
3
The psychological effects of propranolol in the abstinence phase of chronic alcoholics.
Br J Psychiatry. 1971 Dec;119(553):605-6. doi: 10.1192/bjp.119.553.605.
4
Efficacy of chronic propranolol therapy in action tremors of the familial, senile or essential varieties.
N Engl J Med. 1974 May 2;290(18):984-8. doi: 10.1056/NEJM197405022901802.
5
Propranolol in the control of schizophrenic symptoms.
Br Med J. 1974 Dec 14;4(5945):633-5. doi: 10.1136/bmj.4.5945.633.
6
Propranolol antagonism of morphine-influenced behavior.
Brain Res. 1974 Jan 11;65(2):362-7. doi: 10.1016/0006-8993(74)90051-1.
7
Effect of adrenergic beta-blockade on parkinsonian tremor.
Lancet. 1965 Dec 18;2(7425):1259-62. doi: 10.1016/s0140-6736(65)92279-8.
8
Beta-sympathetic blockade in hyperthyroidism.
Lancet. 1966 Mar 19;1(7438):628-31. doi: 10.1016/s0140-6736(66)90825-7.
9
Letter: Propranolol in treatment of migraine in children.
Lancet. 1973 Oct 6;2(7832):799. doi: 10.1016/s0140-6736(73)91074-x.
10
Effect of propranolol on active users of heroin.
Lancet. 1973 Sep 15;2(7829):612. doi: 10.1016/s0140-6736(73)92433-1.
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