Keidar S, Grenadier E, Palant A
Postgrad Med J. 1980 May;56(655):356-8. doi: 10.1136/pgmj.56.655.356.
Hyperthyroidism is a rare side effect of amiodarone treatment. Four patients with this untoward effect are described One patient with mild hyperthyroidism before treatment with amiodarone, developed prolonged severe resistant thyrotoxicosis 6 months after initiation of this drug. A second patient with Wolf-Parkinson-White syndrome and paroxysmal atrial fibrillation was successfully stabilized with amiodarone for 18 months. However, the arrhythmia recurred and the thyroid function tests were found to be elevated. In 2 other patients only slight elevation of the thyroid function tests were found without clinical manifestations 4 months after treatment with amiodarone had been initiated.
甲状腺功能亢进是胺碘酮治疗罕见的副作用。本文描述了4例出现这种不良反应的患者。1例在使用胺碘酮治疗前患有轻度甲状腺功能亢进，在开始使用该药6个月后出现了持续严重的难治性甲状腺毒症。第2例患有预激综合征和阵发性心房颤动的患者，使用胺碘酮成功稳定病情达18个月。然而，心律失常复发，甲状腺功能检查结果升高。另外2例患者在开始使用胺碘酮治疗4个月后，甲状腺功能检查仅轻微升高，无临床表现。
