Ignatowska-Switalska H, Januszewicz P
Prostaglandins Med. 1980 Oct;5(4):289-96. doi: 10.1016/0161-4630(80)90031-2.
Radioimmunoassay with specific antibodies from the Pasteur Institute was used for urinary PGE2 and PGF2 alpha determination in 51 individuals 5 healthy newborn, 9 infants, 15 children and 22 adults. PGE2 excretion rose significantly with increasing age from 15,2 +/- 2,3 pmols/24 h in the newborn up to 940,6 +/- 101,7 pmols/24 h in adults; an even more pronounced increase of PGF2 alpha with age was observed. In infants the ratio PGE2/PGF2 alpha was higher (0,49) than in the children (0,22) but in adults it increased and reached a level of 0,67. In the latter group urinary excretion of Pgs was higher in males than in females but the ratio PGE2/PGF2 alpha was the same in both sexes.
采用巴斯德研究所提供的特异性抗体，通过放射免疫分析法对51名个体（5名健康新生儿、9名婴儿、15名儿童和22名成年人）的尿中前列腺素E2（PGE2）和前列腺素F2α（PGF2α）进行测定。PGE2的排泄量随着年龄的增长而显著增加，从新生儿的15.2±2.3皮摩尔/24小时增加到成年人的940.6±101.7皮摩尔/24小时；观察到PGF2α随年龄增长的增加更为明显。婴儿中PGE2/PGF2α的比值（0.49）高于儿童（0.22），但在成年人中该比值升高并达到0.67。在成年人组中，男性的前列腺素尿排泄量高于女性，但PGE2/PGF2α的比值在两性中相同。
