Nielsen T T, Henningsen P, Bagger J P, Thomsen P E, Eyjolfsson K
Scand J Clin Lab Invest. 1980 Oct;40(6):575-80. doi: 10.3109/00365518009091967.
A significant release of citrate across the myocardium was demonstrated in twenty-two patients with coronary artery disease (CAD) and in ten control subjects in fasting resting state. In both groups, increasingly negative arterio-coronary sinus (A-Cs) plasma citrate differences correlated positively to arterial plasma free fatty acid (FFA)concentrations and negatively to (A-Cs) differences of plasma glucose. This supports the hypothesis that a citrate inhibition of glycolysis at the site of phosphofructokinase is of regulatory importance for myocardial glucose metabolism, and suggests that FFA supress glucose utilization by the heart in many by this mechanism. The capacity of plasma FFA to increase myocardial citrate release was significantly higher in controls than in patients with CAD, and was found to be positively related to myocardial capacity of oxygen consumption as estimated from the product of heart rate and systolic blood pressure during an exercise tolerance test.
在22例冠心病（CAD）患者和10名处于空腹静息状态的对照受试者中，均证实有大量柠檬酸盐穿过心肌。在两组中，动脉-冠状窦（A-Cs）血浆柠檬酸盐差异越来越负，与动脉血浆游离脂肪酸（FFA）浓度呈正相关，与血浆葡萄糖的（A-Cs）差异呈负相关。这支持了以下假设：在磷酸果糖激酶位点柠檬酸盐对糖酵解的抑制对心肌葡萄糖代谢具有调节重要性，并表明FFA在许多情况下通过这种机制抑制心脏对葡萄糖的利用。对照组血浆FFA增加心肌柠檬酸盐释放的能力显著高于CAD患者，并且发现与运动耐力试验期间根据心率和收缩压乘积估算的心肌耗氧能力呈正相关。
