Rocchelli B, Poloni M, Mazzarello P
Schweiz Arch Neurol Neurochir Psychiatr. 1980;127(1):69-77.
Intrathecal IgG synthesis has been studied in neurological patients by both quantitative and qualitative methods. An elevated correlation was found between IgG/Albumin quotient, IgG-Index and IgG SYN: moreover the appearance of oligoclonal IgG bands in CSF seems clearly related to high IgG Index values, as observed by statistical analysis. Nevertheless oligoclonal pattern in CSF is always present in diseases associated with immunological abnormalities, while quantitative parameters may be found elevated also in the diseases without a clear immunological disturbance. The authors stress the great importance of CSF examination by Isoelectric Focusing in the evaluation of intrathecal IgG synthesis in multiple sclerosis.
已经通过定量和定性方法对神经科患者的鞘内IgG合成进行了研究。发现IgG/白蛋白商、IgG指数和IgG SYN之间存在高度相关性：此外，通过统计分析观察到，脑脊液中寡克隆IgG带的出现似乎与高IgG指数值明显相关。然而，脑脊液中的寡克隆模式在与免疫异常相关的疾病中总是存在，而定量参数在没有明显免疫紊乱的疾病中也可能升高。作者强调，在评估多发性硬化症的鞘内IgG合成时，等电聚焦脑脊液检查非常重要。
