Hunziker T, Fehlmann U, Kummer H, Spengler H, Hoigné R
Schweiz Med Wochenschr. 1980 Sep 6;110(36):1295-300.
During 1979 4 patients were observed who developed short episodes of fever as high as 104 degrees F after oral intake of 25--100 mg nomifensine (Alival). In all four cases a clear fever spike was produced by reexposure to the drug. The reaction time was 4--6 hours. this drug-induced fever appeared initially 2--4 weeks after the commencement of Alival therapy. No other cause for the fever was identifiable. In one patient an allergic alveolitis was suspected to be a further reaction. In another patient a concomitant granulomatous hepatitis was possibly also due to this drug. It is probable that the febrile reactions have an allergic mechanism. Allergologic investigations have not yet been completed.
1979年期间，观察到4例患者在口服25 - 100毫克诺米芬辛（阿立伐）后出现高达104华氏度的短期发热。在所有4例病例中，再次接触该药物均出现明显的发热高峰。反应时间为4 - 6小时。这种药物性发热最初出现在阿立伐治疗开始后的2 - 4周。未发现其他发热原因。在1例患者中，怀疑过敏性肺泡炎是另一种反应。在另1例患者中，同时出现的肉芽肿性肝炎可能也归因于该药物。发热反应很可能有过敏机制。过敏学调查尚未完成。
