Elkon D, Kim J A, Huddleston A L, Constable W C
South Med J. 1980 Nov;73(11):1439-42. doi: 10.1097/00007611-198011000-00005.
A retrospective review of women with carcinoma of the urethra is reported. Twelve patients treated between 1947 and 1978 have been characterized as to presenting features, therapy, and prognosis. There average age of patients at diagnosis was 68 years; the most frequent presenting symptom was bleeding (92% of patients); average duration of symptoms before diagnosis was five months. Localized tumors of the distal urethra have been effectively controlled by using interstitial implantation of radioactive sources, five of five patients having no evidence of disease one to ten years after treatment. Our study agrees with reports in the literature on the results of interstitial implantation of radioactive sources. Patients with tumor involving the entire urethra have a poor prognosis, and four of five patients died within the first year after therapy.
本文报告了一项对尿道癌女性患者的回顾性研究。对1947年至1978年间接受治疗的12例患者的临床表现、治疗方法及预后进行了分析。患者确诊时的平均年龄为68岁；最常见的症状是出血（92%的患者）；确诊前症状的平均持续时间为5个月。通过放射性源间质植入术，远端尿道局限性肿瘤得到了有效控制，5例患者中有5例在治疗后1至10年无疾病证据。我们的研究结果与文献中关于放射性源间质植入术的报道一致。肿瘤累及整个尿道的患者预后较差，5例患者中有4例在治疗后第一年内死亡。
