Basset H M, Robins A H
S Afr Med J. 1980 Dec 13;58(24):971-3.
This study investigated the first-pass effect (E) and total hepatic intrinsic clearance (Clint) of propranolol and pindolol by means of an isolated rat liver perfusion model. It was shown that propranolol has a highly significantly greater E and Clint than pindolol. These marked differences between the drugs may be accounted for by the strong initial binding of propranolol to liver sites, a phenomenon possibly related to the greater lipid solubility of propranolol compared with pindolol.
本研究通过离体大鼠肝脏灌注模型，研究了普萘洛尔和吲哚洛尔的首过效应（E）和肝脏总内在清除率（Clint）。结果表明，普萘洛尔的E和Clint比吲哚洛尔高得多，具有高度显著性差异。药物之间的这些显著差异可能是由于普萘洛尔与肝脏部位的强烈初始结合，这一现象可能与普萘洛尔比吲哚洛尔更大的脂溶性有关。
