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[镉盐和锌盐对小鼠体细胞和性细胞无诱变作用]

[Absence of a mutagenic effect of cadmium and zinc salts in mouse somatic and sex cells].

作者信息

Vilkina G A, Pomerantseva M D, Ramaĭia L K

出版信息

Genetika. 1978;14(12):2212-4.

PMID:744480
Abstract

Mutagenic effect of cadmium chloride and zinc chloride on the yield of chromosome aberrations induced in bone marrow cells and the frequency of dominant lethal mutations induced by zinc chloride in male germ mouse cells are studied. Water solutions of CdCl2 and ZnCl2 were injected intraperitoneally to male mice at doses of 4 and 15 mg/kg respectively. The results obtained did not reveal any mutagenic effect of these salts in somatic cells and of ZnCl2 in germ cells of mice.

摘要

研究了氯化镉和氯化锌对小鼠骨髓细胞诱发染色体畸变率以及氯化锌对雄性小鼠生殖细胞诱发显性致死突变频率的诱变作用。分别以4毫克/千克和15毫克/千克的剂量给雄性小鼠腹腔注射氯化镉和氯化锌的水溶液。所得结果未显示这些盐类对小鼠体细胞有任何诱变作用,也未显示氯化锌对小鼠生殖细胞有诱变作用。

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