Gil Recasens M E, de Lourdes Collado M, Hicks J J
Ginecol Obstet Mex. 1978 Dec;44(266):491-506.
The fixed position of trophoblast in the uterus is preceded by zygote orientation and its contact, adhession and fusion with endometrial cell membrane. These interactions take place in a precise site called "implantation site". The identification of this area by the administration of pontamine blue has allowed biochemical studies which showed an increase (in the site) of glycolytic enzymes activity of the pentose cycle, of beta-glucuramidase and of acid and alkaline phosphatase; with a decrease in catepsine D activity. In non implanted tissue, isocitric dehydrogenase activity is decreased. From the biochemical standpoint the implanted endometrium may be different from the rest, which allows a better knowledge of possible molecular mechanisms related with implantation, as well as the possible inhibition with medication.
滋养层在子宫内的固定位置先于受精卵的定位及其与子宫内膜细胞膜的接触、黏附与融合。这些相互作用发生在一个精确的部位，即“着床部位”。通过注射滂胺蓝来识别该区域，从而进行了生化研究，结果显示（在该部位）戊糖循环的糖酵解酶活性、β-葡萄糖醛酸酶以及酸性和碱性磷酸酶活性增加；而组织蛋白酶D活性降低。在未着床的组织中，异柠檬酸脱氢酶活性降低。从生化角度来看，着床的子宫内膜可能与其他部位不同，这有助于更好地了解与着床相关的可能分子机制，以及药物可能的抑制作用。
