用4,4'-亚甲基双（N,N-二甲基）苯胺处理的Fischer 344大鼠甲状腺肿瘤的形态学
Morphology of the neoplasms of the thyroid gland in Fischer 344 rats treated with 4,4'-methylene-bis-(N,N-dimethyl)-benzenamine.
作者信息
Murthy A S
出版信息
Toxicol Lett. 1980 Oct;6(6):391-7. doi: 10.1016/0378-4274(80)90112-5.
PMID:7444979
Abstract
Follicular neoplasms of the thyroid gland developed in 79 of 200 Fischer 344 rats of both sexes, fed either 0.0375% or 0.075% 4,4'-methylene-bis-(N,N-dimethyl)-benzenamine (MDBA) mixed with the diet. Hyperplastic changes in the follicular epithelium occurred in 12 rats fed the higher concentration of this chemical. One of 40 control rats had a follicular carcinoma of the thyroid gland.
摘要
在200只雌雄Fischer 344大鼠中，79只喂食了含0.0375%或0.075% 4,4'-亚甲基双（N,N-二甲基）苯胺（MDBA）的混合饲料，甲状腺出现了滤泡性肿瘤。12只喂食该化学物质较高浓度饲料的大鼠，其滤泡上皮发生了增生性变化。40只对照大鼠中有1只患有甲状腺滤泡癌。
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