马来酸二乙酯对大鼠丙烯酰胺诱导的神经病变的影响。

Effect of diethyl maleate on acrylamide induced neuropathy in rats.

作者信息

Dixit R, Husain R, Seth P K, Mukhtar H

出版信息

Toxicol Lett. 1980 Oct;6(6):417-21. doi: 10.1016/0378-4274(80)90116-2.

Abstract

Pre-administration of diethyl maleate (DEM) to rats resulted in an earlier onset and development of hind limb paralysis following acrylamide administration than in rats treated with acrylamide only. A marked depletion of brain biogenic amine content and of glutathione levels was also observed in the DEM pretreated groups. Depletion of cellular glutathione would appear to lead to an increased neurotoxicity of acrylamide.

摘要

给大鼠预先注射马来酸二乙酯（DEM），与仅用丙烯酰胺处理的大鼠相比，注射丙烯酰胺后后肢麻痹的发作和发展更早。在预先用DEM处理的组中还观察到脑生物胺含量和谷胱甘肽水平明显降低。细胞内谷胱甘肽的消耗似乎会导致丙烯酰胺的神经毒性增加。