Enhancement of pulmonary metastases following the intravenous infusion of a suspension of ellagic acid in traumatized rats.

A significant shortening of the silicone and glass clotting times and a reduction of oozing from the exposed femoral veins was observed following the infusion of EA. Ellagic acid significantly enhanced metastases formation; and in traumatized animals its effect was more pronounced. No definite explanation on the combined effect of trauma and EA can be offered at this time; however several possibilities are discussed. There was no obvious untoward side effect of EA in any of the animals studied.