甲氧苄啶-磺胺甲恶唑对华法林的增效作用。
Potentiation of warfarin by trimethoprim-sulfamethoxazole.
作者信息
Kaufman J M, Fauver H E
出版信息
Urology. 1980 Dec;16(6):601-3. doi: 10.1016/0090-4295(80)90568-3.
PMID:7445308
Abstract
Potentiation of warfarin by trimethoprim-sulfamethoxazole (TMP-SMX) has been reported occasionally but not in the urologic literature. Three cases are presented in which significant bleeding developed when TMP-SMX was added for the patient already on warfarin anticoagulants. The mechanism of this interaction is uncertain but probably involves competitive protein binding by the two drugs.
摘要
据报道，甲氧苄啶-磺胺甲恶唑（TMP-SMX）偶尔会增强华法林的作用，但泌尿外科文献中未见相关报道。本文介绍了三例病例，在已服用华法林抗凝剂的患者中加用TMP-SMX后出现了严重出血。这种相互作用的机制尚不确定，但可能涉及两种药物竞争性蛋白结合。
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