Stachura J, Skrzatek B, Urban A
Folia Histochem Cytochem (Krakow). 1978;16(4):299-305.
Investigations of Culling et al. showed the possibility of using KOH/PAS effect (visualisation of C7 and C8O-acylated sialic acids characteristic to colon mucin) for differential diagnosis of metastatic colorectal cancer. Our investigations revealed, however, KOH/PAS positive mucin prevailing in some cases of gallbladder, pancreatic and gastric cancer. This makes serious limitation of Culling method in the routine diagnostic work.
库林等人的研究表明,利用KOH/PAS效应(可视化结肠黏蛋白特有的C7和C8 O-酰化唾液酸)对转移性结直肠癌进行鉴别诊断具有可能性。然而,我们的研究发现,在某些胆囊癌、胰腺癌和胃癌病例中也存在KOH/PAS阳性黏蛋白。这使得库林方法在常规诊断工作中受到严重限制。