[Seasonal fluctuations in the enteropathogenic properties of vibrios].

Seasonal biorhythms with the intermittent periods of activity and rest in the manifestation of the enteropathogenic properties of cholera and NAG vibrios have been revealed. In the climatic conditions of the Rostov region the period of maximum activity in respect of this characteristic is shown to fall on spring and summer, while the period to rest is shown to fall on autumn and winter. In highly toxigenic cultures the phase of rest has been found to be considerably shorter than in cultures with low toxigenicity. The cyclic changes in the toxin-producing function of vibrios are suggested to be the main reason of the seasonal character of infections caused by cholera and NAG vibrios.