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[心肌松弛现象的建模]

[Modelling of relaxation phenomena in the myocardium].

作者信息

Wussling M, Szymanski G

出版信息

Acta Biol Med Ger. 1980;39(5):583-90.

PMID:7445904
Abstract

A model describing relaxation phenomena on heart muscle preparations is proposed, permitting characterization of diastolic oscillations (aftercontractions) that are considered as being damped harmonic oscillations superposed an exponentially descending carrier function (oscillating case). If there is a high damping ratio diastolic oscillations cannot be observed except the phenomenon of hyperrelaxation. Relaxation without oscillations corresponds to the aperiodic case. Examples of relaxation time courses resulting from right ventricular rabbit papillary muscles (isometric conditions) as well as relaxation parameters and approximation curves obtained by the aid of the table computer EMG 666 are given. The model is realized by an electrical analog which is based on a hypothesis concerning the calcium sequestration in the myoplasm.

摘要

提出了一个描述心肌制剂松弛现象的模型,该模型能够对舒张期振荡(后收缩)进行表征,这些舒张期振荡被视为叠加在指数下降载波函数上的阻尼谐波振荡(振荡情况)。如果阻尼比很高,则除了超松弛现象外,无法观察到舒张期振荡。无振荡的松弛对应于非周期性情况。给出了右心室兔乳头肌(等长条件)产生的松弛时间过程的示例,以及借助台式计算机EMG 666获得的松弛参数和近似曲线。该模型由一个电模拟实现,该电模拟基于关于肌浆中钙螯合的假设。

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