Goisis C, Goisis F, Tammiso R
Acta Eur Fertil. 1980 Mar;11(1):61-85.
Our results show in an unquestionable way that both the steroid (ethinylestradiol) and non-steroid (Ralone) estrogens studied by us were absorbed percutaneously by the rat. They also demonstrate that both estrogens affected target organs in a quite similar way being proportionally dependent upon the 1-to-1,000 ratio existing between them, as established on the basis of a known activity parameter. When one of the two estrogens is given for therapeutical purposes its systemic effects are of a dose-related type.
我们的结果明确显示，我们所研究的甾体雌激素（炔雌醇）和非甾体雌激素（拉洛内）均可经大鼠皮肤吸收。结果还表明，两种雌激素对靶器官的影响方式非常相似，根据已知活性参数确定，二者的比例为1:1000，且呈比例相关。当两种雌激素中的一种用于治疗目的时，其全身效应呈剂量相关型。
