Janczewska H
Acta Physiol Pol. 1980 May-Jun;31(3):297-303.
The effecs of two different inhibitors of prostaglandin synthesis--aspirin and indomethacin--on the blood flow in the vascular bed of the hindleg of vagotomized animals were studied before, during and after muscular activity of this limb. The responses of resistance and capacitance vessels were recorded simultaneously. Muscular contractions were evoked stimulating electrically (4 impulses/second) the peripheral part of the sciatic nerve. It was found that both inhibitors reduced exercise hyperaemia and postexercise hyperaemia. The response of the capacitance vessels was also reduced during muscular contractions. The obtained results confirmed that endogenous prostaglandins participate in the vascular response during exercise in the precapillary and postcapillary sections of microcirculation in the muscles. The particularly important effect of aspirin on postexercise hyperaemia in dogs in relation to cats is stressed.
研究了两种不同的前列腺素合成抑制剂——阿司匹林和消炎痛——在迷走神经切断动物后肢血管床肌肉活动前、活动期间和活动后的血流影响。同时记录了阻力血管和容量血管的反应。通过电刺激（每秒4次脉冲）坐骨神经外周部分诱发肌肉收缩。发现两种抑制剂均降低了运动性充血和运动后充血。在肌肉收缩期间，容量血管的反应也降低。所得结果证实内源性前列腺素参与了运动期间肌肉微循环毛细血管前和毛细血管后节段的血管反应。强调了阿司匹林对犬运动后充血相对于猫的特别重要作用。
