Diquet B, Colin J N, Singlas E
Ann Biol Clin (Paris). 1980;38(4):223-5.
A rapid and sensitive analytic method for metronidazole (Flagyl) using high performance liquid chromatography is described; the use of a column filled with grafted silicium, lichrosorb RP 8, permits the direct injection of a plasma treated with perchloric acid and then centrifuged. The coefficients of capacity of metronidazole and of the internal standard solution were respectively 4,8 and 11,5. This technic permits one to carry out as a routine estimations of metronidazole, used in the treatment anaerobic gram negative septicemias.
描述了一种使用高效液相色谱法测定甲硝唑（灭滴灵）的快速灵敏分析方法；使用填充有接枝硅胶（利口乐RP 8）的色谱柱，可直接进样经高氯酸处理后离心的血浆。甲硝唑和内标溶液的容量系数分别为4.8和11.5。该技术可作为常规方法用于测定治疗厌氧革兰氏阴性败血症时使用的甲硝唑。
