Gilman M J, Wang K P
Am Rev Respir Dis. 1980 Nov;122(5):721-4. doi: 10.1164/arrd.1980.122.5.721.
In order to determine if the diagnostic yield of the transbronchial lung biopsy in sarcoidosis is dependent upon the number of biopsies, a study was designed to examine individual specimens from 6 biopsies in patients with Stage II sarcoidosis. It was found that the probability of obtaining a positive specimen per biopsy was 46%, and this percentage remained constant for each biopsy. The diagnostic yield followed a logarithmic curve, gradually increasing from 1 through 4 biopsies until about 90% of true positive diagnoses were obtained, then approaching a plateau with successive biopsies. We therefore recommend that 4 transbronchial lung biopsies are sufficient to diagnose stage II sarcoidosis in the majority of patients with diffuse lung disease.
为了确定经支气管肺活检在结节病中的诊断率是否取决于活检次数，设计了一项研究，对Ⅱ期结节病患者的6次活检的单个标本进行检查。发现每次活检获得阳性标本的概率为46%，且每次活检该百分比保持不变。诊断率呈对数曲线，从1次活检到4次活检逐渐增加，直到获得约90%的真阳性诊断，然后随着连续活检接近平台期。因此，我们建议，对于大多数弥漫性肺疾病患者，4次经支气管肺活检足以诊断Ⅱ期结节病。
